Active inter-cellular forces in collective cell motility
نویسندگان
چکیده
منابع مشابه
Collective cell guidance by cooperative intercellular forces
Cells comprising a tissue migrate as part of a collective. How collective processes are coordinated over large multi-cellular assemblies has remained unclear, however, because mechanical stresses exerted at cell-cell junctions have not been accessible experimentally. We report here maps of these stresses within and between cells comprising a monolayer. Within the cell sheet there arise unantici...
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Fundamental biological processes including morphogenesis, tissue repair and tumour metastasis require collective cell motions1–3, and to drive these motions cells exert traction forces on their surroundings4. Current understanding emphasizes that these traction forces arise mainly in ‘leader cells’ at the front edge of the advancing cell sheet5–9. Our data are contrary to that assumption and sh...
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In this article, we review physics-based models of collective cell motility. We discuss a range of techniques at different scales, ranging from models that represent cells as simple self-propelled particles to phase field models that can represent a cell's shape and dynamics in great detail. We also extensively review the ways in which cells within a tissue choose their direction, the statistic...
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ژورنال
عنوان ژورنال: Journal of The Royal Society Interface
سال: 2020
ISSN: 1742-5689,1742-5662
DOI: 10.1098/rsif.2020.0312